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Williams Hematology

by Ernest Beutler,Kenneth Kaushansky,Marshall A. Lichtman

Publisher: McGraw-Hill Medical/Jaypee Brothers Medical Publishers

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About the book

Edition after edition, Williams Hematology has guided generations of clinicians, biomedical researchers, and trainees in many disciplines through the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood cells and coagulation proteins. The book begins with the evaluation of the patient and progresses to the molecular and cellular underpinnings of normal and pathological hematology. Subsequent sections present disorders of the erythrocyte, granulocytes and monocytes, lymphocytes and plasma cells, malignant myeloid and lymphoid diseases, hemostasis and thrombosis, and transfusion medicine. Featuring a brand-new full-color presentation, the Eighth Edition of Williams Hematology is extensively revised to reflect the latest views of experts in the field. Two new chapters examine the importance of genomics in hematology and cell therapy for tissue replacement, whereas other chapters have been revised to incorporate the newest clinical approaches to the leukemias and lymphomas, and the application of targeted therapy in the treatment of hematologic disorders. New to this Edition: Full-color presentation conveniently integrates images of blood and tissue findings where they are cited in the text Two additional chapters, “Genomics and Epigenetics,” and “Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement,” offer insights into the application of genomic and monoclonal therapies to hematology and emphasize their role in improving diagnostic and therapeutic methods Expanded coverage of non-Hodgkin lymphoma includes separate chapters on its constituent diseases, providing an in-depth assessment of the diagnosis and management of these disorders A comprehensive discussion of erythrocytosis and thrombocytosis reviews reactive and malignant forms of myeloproliferation, encompassing new genetic advances in these disorders along with more targeted therapeutic approaches Companion CD includes a large selection of morphologies, illustrations, and drawings from the book, in a presentation-ready PowerPoint format Table of contents Contributors Preface PART I: CLINICAL EVALUATION OF THE PATIENT 1. Initial Approach to the Patient: History and Physical Examination, Marshal A. Lichtman and Ernest Beutler 2. Examination of Blood Cells, Daniel H. Ryan 3. Examination of the Marrow, Daniel H. Ryan PART II: THE ORGANIZATION OF THE LYMPHOHEMATOPOIETIC TISSUES 4. Structure of the Marrow and the Hematopoietic Microenvironment, Mark J. Koury and Marshall A. Lichtman 5. The Organization and Structure of Lymphoid Tissues, Thomas J. Kipps PART III: EPOCHAL HEMATOLOGY 6. Hematology of the Fetus and Newborn, James Palis and George B. Segel 7. Hematology during Pregnancy, Martha P. Mims and Josef T. Prchal 8. Hematology in Older Persons, William B. Ershler and Dan L. Longo PART IV: MOLECULAR AND CELLULAR HEMATOLOGY 9. Genetic Principles and Molecular Biology, Ernest Beutler 10. Genomics and Epigenetics, Lynn B. Jorde 11. Cytogenetics and Molecular Abnormalities, Lucy A. Godley and Michelle M. Le Beau 12. Apoptosis, Roberta A. Gottlieb 13. Cell-Cycle Regulation and Hematologic Disorders, Mathias Schmid and Dennis A. Carson 14. Signal Transduction Pathways, Kenneth Kaushansky 15. The Cluster of Differentiation Antigens, Thomas J. Kipps 16. Hematopoietic Stem Cells, Progenitors, and Cytokines, Kenneth Kaushansky 17. The Inflammatory Process, Jeffrey S. Warren and Peter A. Ward 18. Innate Immunity, Bruce Beutler 19. Dendritic Cells and the Control of Innate Adaptive Immunity, Madhav Dhodapkar and Ralph M. Steinman PART V: THERAPEUTIC PRINCIPLES 20. Pharmacology and Toxicity of Antineoplastic Drugs, Bruce A. Chabner, Jeffrey Barnes, James Cleary, Andrew Lane, Constantine Mitsiades, and Paul Richardson 21. Principles of Hematopoietic Cell Transplantation, Robert Lowsky and Robert S. Negrin 22. Treatment of Infections in the Immunocompromised Host, Steven Beutler and Lisa Beutler 23. Principles of Antithrombotic Therapy, Charles W. Francis and Mark Crowther 24. Principles of Immune Cell Therapy, Carolina Berger and Stanley R. Riddell 25. Principles of Vaccine Therapy, Sattva S. Neelapu and Larry W. Kwak 26. Principles of Therapeutic Apheresis: Indications, Efficacy, and Complications, Bruce C. McLeod 27. Principles of Gene Transfer for Therapy, Januario E. Castro and Thomas J. Kipps 28. Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement, Armand Keating PART VI: THE ERYTHROCYTE 29. Morphology of the Erythron, Brian S. Bull and Paul C. Herrmann 30. Composition of the Erythrocyte, Ernest Beutler 31. Production of Erythrocytes, Josef T. Prchal 32. Destruction of Erythrocytes, Ernest Beutler 33. Clinical Manifestations and Classification of Erythrocyte Disorders, Josef T. Prchal 34. Aplastic Anemia: Acquired and Inherited, George B. Segel and Marshall A. Lichtman 35. Pure Red Cell Aplasia, Neal S. Young 36. Anemia of Chronic Renal Disease, Jaime Caro and Ubaldo Martinez Outschoorn 37. Anemia of Chronic Disease, Tomas Ganz 38. Anemia of Endocrine Disorders, Xylina T. Gregg and Josef T. Prchal 39. The Congenital Dyserythropoietic Anemias, Jean Delaunay 40. Paroxysmal Nocturnal Hemoglobinuria, Charles J. Parker 41. Folate, Cobalamin, and Megaloblastic Anemias, Ralph Green 42. Disorders of Iron Metabolism, Ernest Beutler 43. Anemia Resulting from Other Nutritional Deficiencies, Ralph Green 44. Anemia Associated with Marrow Infiltration, Archana M. Agarwal and Josef T. Prchal 45. The Red Blood Cell Membrane and Its Disorders: Hereditary Spherocytosis, Elliptocytosis, and Related Diseaes, Patrick G. Gallagher 46. Disorders of Red Cells Resulting from Enzyme Abnormalities, Wouter W. van Solinge and Richard van Wijk 47. The Thalassemias: Disorders of Globin Synthesis, David J. Weatherall 48. Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities, Kavita Natarajan, Tim M. Townes, and Abdullah Kutlar 49. Methemoglobinemia and Other Dyshemoglobinemias, Neeraj Agarwal and Josef T. Prchal 50. Hemolytic Anemia Resulting from Physical Injury to Red Cells, Kelty R. Baker and Joel Moake 51.Hemolytic Anemia Resulting from Chemical and Physical Agents, Brian S. Bull and Paul C. Herrmann 52. Hemolytic Anemia Resulting from Infections with Microorganisms, Marshall A. Lichtman 53. Hemolytic Anemia Resulting from Immune Injury, Charles H. Packman 54. Alloimmune Hemolytic Disease of the Fetus and Newborn, Jayashree Ramasethu and Naomi L. C. Luban 55. Hypersplenism and Hyposlenism, Jaime Caro and Ubaldo Martinez Outschoorn 56. Primary and Secondary Polycythemias (Erythrocytosis), Josef T. Prchal 57. The Porphyrias, John D. Phillips and Karl E. Anderson 58. Hereditary and Acquired Sideroblastic Anemias, Prem Ponka and Josef T. Prchal PART VII: NEUTROPHILS, EOSINOPHILS, BASOPHILS, AND MAST CELLS 59. Morphology of Neutrophils, Eosinophils, and Basophils, C. Wayne Smith 60. Composition of Neutrophils, C. Wayne Smith 61. Production, Distribution, and Fate of Neutrophils, C. Wayne Smith 62. Eosinophils and Their Disorders, Andrew J. Wardlaw 63. Basophils and Mast Cells and Their Disorders, Stephen J. Galli, Dean D. Metcalfe, Daniel A. Arber, and Ann M. Dvorak 64. Classification and Clinical Manifestations of Neutrophil Disorders, Marshall A. Lichtman 65. Neutropenia and Neutrophilia, David C. Dale 66. Disorders of Neutrophil Function, Niels Borregaard and Laurence A. Boxer PART VIII: MONOCYTES AND MACROPHAGES 67. Morphology of Monocytes and Macrophages, Steven D. Douglas and Florin Tuluc 68. Biochemistry and Functions of Monocytes and Macrophages, Annette Pluddemann and Siamon Gordon 69. Production, Distribution, and Fate of Monocytes and Macrophages, Siamon Gordon and Annette Pluddemann 70. Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages, Marshall A. Lichtman 71. Monocytosis and Monocytopenia, Marshall A. Lichtman 72. Inflammatory and Malignant Histiocytosis, Kenneth L. McClain and Carl E. Allen 73. Lipid Storage Diseases, Ari Zimran and Deborah Elstein PART IX: LYMPHOCYTES AND PLASMA CELLS 74. Morphology of Lymphocytes and Plasma Cells, H. Elizabeth Broome 75. Composition and Biochemistry of Lymphocytes and Plasma Cells, Thomas J. Kipps 76. Lymphopoiesis, Gay M. Crooks 77. Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production, Thomas J. Kipps 78. Functions of T Lymphocytes: T-Cell Receptors for Antigen, Thomas J. Kipps 79. Functions of Natural Killer Cells, Giorgio Trinchieri and Lewis L. Lanier 80. Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders, Thomas J. Kipps 81. Lymphocytosis and Lymphocytopenia, Thomas J. Kipps 82. Immunodeficiency Diseases, Hans D. Ochs and Luigi D. Notarangelo 83. Hematologic Manifestations of Acquired Immunodeficiency Syndrome, Erin Gourley Reid 84. Mononucleosis Syndromes, Robert F. Betts PART X: NEOPLASTIC MYELOID DISEASES 85. Classification and Clinical Manifestations of the Clonal Myeloid Disorders, Marshall A. Lichtman 86. Polycythemia Vera, Josef T. Prchal and Jaroslav F. Prchal 87. Essential Thrombocythemia, Philip A. Beer and Anthony R. Green 88. Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Myelogenous Leukemia), Jane L. Liesveld and Marshall A. Lichtman 89. Acute Myelogenous Leukemia, Jane L. Liesveld and Marshall A. Lichtman 90. Chronic Myelogenous Leukemia and Related Disorders, Jane L. Liesveld and Marshall A. Lichtman 91. Primary Myelofibrosis, Marshall A. Lichtman and Ayalew Tefferi PART XI: NEOPLASTIC LYMPHOID DISEASES 92. Classification of Malignant Lymphoid Disorders, Thomas J. Kipps and Huan-You Wang 93. Acute Lymphoblastic Leukemia, Ching-Hon Pui 94. Chronic Lymphocytic Leukemia and Related Diseases, Thomas J. Kipps 95. Hairy Cell Leukemia, Darren Sigal and Alan Saven 96. Large Granular Lymphocytic Leukemia, Thomas P. Loughran and Marshall E. Kadin 97. General Considerations of Lymphoma: Epidemiology, Etiology, Heterogeneity, and Primary Extranodel Disease, Kenneth A. Foon and Marshall A. Lichtman 98. Pathology of Malignant Lymphomas, Randy D. Gascoyne and Kenneth A. Foon 99. Hodgkin Lymphoma, Sandra J. Horning 100. Diffuse Large B-Cell Lymphoma, Michael Boyiadzis and Kenneth A. Foon 101. Follicular Lymphoma, Oliver W. Press 102. Mantle Cell Lymphoma, Jorge E. Romaguera and Peter W. McLaughlin 103. Marginal Zone B-Cell Lymphomas, Emanuele Zucca 104. Burkitt Lymphoma, Jonathan W. Friedberg and Archibald S. Perkins 105. Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sezary Syndrome), Larisa J. Geskin 106. Mature T-Cell and Natural Killer Cell Lymphomas, Oscar B. Goodman, Jr. and Nam H. Dang 107. Plasma Cell Neoplasms: General Considerations, H. Elizabeth Broome 108. Essential Monoclonal Gammopathy, Marshall A. Lichtman 109. Myeloma, Frits van Rhee, Elias Anaissie, Edgardo Angtuaco, Twyla Bartel, Joshua Epstein, Bijay Nair, John Shaughnessy, Shmuel Yaccoby, and Bart Barlogie 110. The Amyloidoses, Vaishali Sanchorawala, Daniel R. Jacobson, David C. Seldin, and Joel N. Buxbaum 111. Macroglobulinemia, Steven P. Treon and Giampaolo Merlini 112. Heavy-Chain Disease, Dietlind L. Wahner-Roedler and Robert A. Kyle PART XII: HEMOSTATIS AND THROMBOSIS 113. Megakaryopoiesis and Thrombopoiesis, Kenneth Kaushansky 114. Platelet Morphology, Biochemistry, and Function, Susan S. Smyth, Sidney Whiteheart, Joseph E. Italiano, Jr. and Barry S. Coller 115. Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostatis, Dougald M. Monroe, III, Maureane Hoffman, and Harold R. Roberts 116. Control of Coagulation Reactions, John H. Griffin 117. Vascular Function in Hemostatis, Katherine A. Hajjar, Aaron J. Marcus, and William Muller 118. Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostatis, Uri Seligsohn and Kenneth Kaushansky 119. Thrombocytopenia, Reyhan Diz-Kucukkaya, Junmei Chen, Amy Geddis, and Jose A. Lopez 120. Reactive Thrombocytosis, Kenneth Kaushansky 121. Hereditary Qualitative Platelet Disorders, Barry S. Coller, Deborah L. French, and A. Koneti Rao 122. Acquired Qualitative Platelet Disorders, Charles S. Adams, Sanford J. Shattil, and Joel S. Bennett 123. The Vascular Purpuras, Doru T. Alexandrescu and Richard L. Gallo 124. Hemophilia A and Hemophilia B, Harold R. Roberts, Nigel S. Key, adn Miguel A. Escobar 125. Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors, Uri Seligsohn, Ariella Zivelin, and Ophira Salomon 126. Hereditary Fibrinogen Abnormalities, Marguerite Neerman-Arbez and Philippe de Moerloose 127. Von Willebrand Disease, Jill Johnsen and David Ginsburg 128. Antibody-Mediated Coagulation Factor Deficiencies, Pete Lollar 129. Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation, Ton Lisman and Philip G. De Groot 130. Disseminated Intravascular Coagulation, Marcel Levi and Uri Seligsohn 131. Hereditary Thrombophilia, Uri Seligsohn and Aharon Lubetsky 132. The Antiphospholipid Syndrome, Jacob H. Rand 133. Antibody-Mediated Thrombotic Disorders: Thrombotic-Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia, J. Evan Sadler and Mortimer Poncz 134. Venous Thrombosis, Gary E. Raskob, Russell D. Hull, and Graham F. Pineo 135. Atherothrombosis: Disease Initiation, Progression, and Treatment, Emile R. Mohler III and Andrew I. Schafer 136. Fibrinolysis and Thrombolysis, Katherine A. Hajjar and Jia Ruan PART XIII: TRANSFUSION MEDICINE 137. Erythrocyte Antigens and Antibodies, Marion E. Reid 138. Human Leukocyte and Platelet Antigens, Myra Coppage, David Stroncek, Janice McFarland, and Neil Blumberg 139. Blood Procurement and Screening, Jeffrey McCullough 140. Red Cell Transfusion, Norma B. Lerner, Majed A. Rafaai, and Neil Blumberg 141. Preservation and Clinical Use of Platelets, Mike Murphy and Ralph Vassallo Index

Details of the book

Book :
Williams Hematology
Book ID :
42415
Author :
Ernest Beutler,Kenneth Kaushansky,Marshall A. Lichtman
ISBN 13 :
9780071621519
Year of Publication :
2010
Edition :
Eighth Edition
Publisher :
McGraw-Hill Medical/Jaypee Brothers Medical Publishers
Binding :
Hardcover
Pages :
2460
Weight :
1 kg
Illustrations :
1 DVD & illustrations

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